Interestingly, overexpression of DOK7 restrained cell proliferation both in MDA-MB-231 and SKBR3 cells, while repression of PTEN expression using PTEN siRNA or SF1670 (PTEN inhibitor) rescued the tumor-inhibiting effect induced by DOK7 overexpression (Figure 6(c)). This evidence concerns the gene PTEN and neoplasm.