These data led to an important speculation that global DNA binding proteins that paradoxically cause specific intellectual phenotypes when dysregulated, such as MeCP2 in RTT or BRG1 in Coffin-Siris syndrome, may be regulated by specific lncRNAs like Evf2. RNA immunoprecipitation of mouse cerebellum robustly pulled down the retinal non-coding RNA (Rncr3), followed by metastasis associated lung adenocarcinoma transcript 1 (Malat1) (Maxwell et al., 2013). This evidence concerns the gene MALAT1 and Coffin-Siris syndrome.