MECP2 and schizophrenia: Also, there are reports of males with MECP2 mutations that are not known pathogenic RTT mutations who are affected, but not with classical RTT (Neul et al., 2019), and some where the clinical presentation includes psychiatric disorders such as schizophrenia (Cohen et al., 2002; Villard, 2007; McCarthy et al., 2014; Curie et al., 2017; Sheikh et al., 2018), bipolar disorder (Sheikh et al., 2016), and Asperger’s (Curie et al., 2017).