While Trifafta provides benefits to the majority of CF patients including those carrying one or two alleles of the dF508 mutation (Heijerman et al., 2019; Middleton et al., 2019), the consensus in the community is that CF is far from being cured and continued efforts should be dedicated to the development of novel therapeutics, for example gene editing mediated correction of CFTR mutations. This evidence concerns the gene CFTR and cystic fibrosis.