Comparing to CF rodent models (i.e., mice and rats), observations from the ΔF508/KO rabbit generated from the present work highly suggest that ΔF508 rabbits may be more clinically relevant, i.e., manifesting some typical CF phenotypes that rodent models failed to demonstrate, in line with our recent findings in the CFTR-KO rabbits (Xu et al., 2020). This evidence concerns the gene CFTR and cystic fibrosis.