The possible association with the progression of PC was first shown for genes ZC2HC1A, CLPB, PRPF19, MPST, GIMAP6, BET1, MIR29B2CH6, and LINC02001. All listed genes showed strong correlations with PFS and thus could be considered as potential prognostic markers. This evidence concerns the gene BET1 and pachyonychia congenita.