The possible association with the progression of PC was first shown for genes ZC2HC1A, CLPB, PRPF19, MPST, GIMAP6, BET1, MIR29B2CH6, and LINC02001. All listed genes showed strong correlations with PFS and thus could be considered as potential prognostic markers. The gene discussed is CLPB; the disease is pachyonychia congenita.