A few human orthologs in the mouse of LY6 include LY6E, LY6K, Lynx1, Slurp1, and Gpihbp1. Knockout of these genes results in embryonic lethality, infertility in male mice, increased visual cortex plasticity, palmoplantar keratoderma with metabolic and neuromuscular abnormal phenotypes, and hypertriglyceridemia phenotype. This evidence concerns the gene GPIHBP1 and hereditary palmoplantar keratoderma.