By constructing a PPI network and combining ChIP-seq data, we obtained four potential target genes, SPTAN1, SLC25A17, IKBKB, and ERH. These hub genes all had binding sites with PTTG1. Interestingly, these genes had been reported as tumor related, and SPTAN1 was a family of filamentous cytoskeletal proteins that acted as an essential scaffold protein for stabilizing the plasma membrane and organizing intracellular organelles. Here, IKBKB is linked to neoplasm.