NLRP3 and hemolytic-uremic syndrome: However, the question remains to be answered is how the Nlrp3 inflammasome activation induced by Stx2 further causes HUS, by increasing the renal sensitivity to the Stx2 subunit A via upregulating the expression of Gb3 receptor on renal cell membrane, or by excessive inflammatory response via recruiting leukocytes to the renal local tissue.