Histopathological examination of the kidney showed that more infiltration of multifocal inflammatory cells (mainly neutrophils), small abscess, pyonephrosis, renal tubular deterioration and atrophy, lumen dilatation, and leucocytes casts in WT mice treated with Stx2/LPS (WT-Stx2/LPS group) (Figure 6B), while there was almost no abnormal findings in the mice from the WT-PBS group (Figure 6A) and the Nlrp3-/- -Stx2/LPS group (Figure 6C). The gene discussed is NLRP3; the disease is abscess.