STX2 and hemolytic-uremic syndrome: Compared with the mock PBS-WT group, the mice in Stx2/LPS group as HUS model had a significantly higher level of serum CRE (69.47 ± 12.74 μmol/ml vs 14.63 ± 4.89 μmol/ml, p<0.001), BUN (67.07 ± 20.80 mmol/ml vs 13.24 ± 7.17mmol/ml, p=0.001) and IL-1β (257.13 ± 108.18 pg/ml vs 24.86 ± 34.55 pg/ml, p<0.001) (Figures 7A–C).