STX2 and hemolytic-uremic syndrome: Compared with the HUS mice in Stx2/LPS group, the mice pretreated with Oridonin, MCC950 and CY-09 were all protected by postponing the death (P=0.02 for MCC950, p=0.002 for CY09, p<0.001 for Oridonin) although there is not difference in survival rate among them at day 10 pi (Figure 7D).