Meanwhile, we found that the targeted genes in the circRNA-miRNA-mRNA network were involved in immunity-related signaling pathways, such as herpes simplex infection, cell adhesion molecules (CAMs), focal adhesion, tight junction, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway, and NF-κB signaling pathways (61). The gene discussed is NFKB1; the disease is herpes simplex infectious disease.