In a colon cancer model HMW-HA binding to TLR4 on cancer cells blocks TLR4 activation by LPS (38).This raises a question as to whether endogenous HA binding to TLR4 on the basolateral surface of LGR5+ crypt epithelial cells blocks TLR4 activation by LPS. The gene discussed is TLR4; the disease is malignant colon neoplasm.