It is interesting to note that dampening of the ADP response, that occurs during CLL disease progression, is attributable exclusively to selective disruption of the negative regulatory pathways (e.g. SIRPα, HDAC7, ship1) rather than the activating pathways (e.g. SYK, BTK, PI3K, SLAMF7). Here, PIK3CD is linked to B-cell chronic lymphocytic leukemia.