NFKB1 and Sepsis: Downregulated TLR4 & NF-κβ & inhibited induction of IL-1β, IL-6, IFN-γ, TNFα in liver & kidney in rat model of LPS-induced sepsis. NF-κB also downregulated in the heart, with increased survival (227).Similar results have been reported after sterile injury (228).