AKT1 and neoplasm: During in vitro and in vivo studies, apart from observing the effects on tumor cell proliferation, the related signaling pathways were explored, including the NF-κB and p38 MAPK signaling cascades mediated by TNFR1 in hepatocellular carcinoma cells (compound Kushen injection) (85) and the AKT pathway in gastric cancer and pancreatic cancer cells (Astragalus polysaccharide) (86, 87).