Moreover, the glomerular expression of inflammatory cytokines related to the NF-κB pathway, including Il1b and Il6, was higher in the UUO kidney at 21 days following obstruction. Therefore, we concluded that the TLR-mediated NF-κB pathway plays an important role in the pathogenesis of GL in the obstructive kidney. This evidence concerns the gene NFKB1 and medical procedure.