Combined LMP2 and LMP7 inhibition not only attenuated macrophage phagocytosis of antibody-coated platelets by decreasing the expression of FcγRI and FcγRIII in ITP mice or patients, but also inhibited the activation of CD4+ T cells and the secretion of Th1 cytokines in patients with ITP. The gene discussed is PSMB9; the disease is autoimmune thrombocytopenic purpura.