To examine the potential role of ONX-0914 in Th cell regulation, CD4+ T cells from ITP patients were magnetically sorted and cultured in vitro in the presence of DMSO, 300 nM ML604440 or 30 nM ONX 0914, and then stimulated with anti-CD3/CD28. This evidence concerns the gene CD4 and autoimmune thrombocytopenic purpura.