Combined LMP2 and LMP7 inhibition not only attenuated macrophage phagocytosis of antibody-coated platelets by decreasing the expression of FcγRI and FcγRIII in ITP mice or patients, but also inhibited the activation of CD4+ T cells and the secretion of Th1 cytokines in patients with ITP. This evidence concerns the gene PSMB8 and autoimmune thrombocytopenic purpura.