AIM2 and injury: Besides, in LPS-induced mouse model of acute lung injury (ALI), HMGB1 can simultaneously activate the TLR4, TLR2, and RAGE/NF-κB signaling pathways to promote the activation of absent in melanoma 2 (AIM2) inflammasome in macrophage and the polarization of M1 macrophages, followed by production of interleukin−1β (IL-1β) and IL-6 (56).