In line, genetical or antibody-mediated depletion of CD8+ T-cells in PI3Kγ−/− mice caused a reduced tumor control but no alterations in proliferation or production of IFNγ or GzmB of PI3Kγ-deficient T-cells isolated from either naïve or tumor bearing mice have been observed ex vivo (96). The gene discussed is CD8A; the disease is neoplasm.