Trafficking of CLL cells is regulated by stromal cells and NLCs in the lymph nodes that secrete chemokines including C-X-C motif chemokine ligand (CXCL)12, CXCL13, C-C motif ligand (CCL)19, and CCL21 (110). The gene discussed is CXCL13; the disease is B-cell chronic lymphocytic leukemia.