And a reduced proliferation of CD8+ T-cells has been observed after PI3Kδ inhibitor treatment in vivo in the preclinical TCL1 AT model of CLL (134) as well as in another model, in which OVA-expressing TCL1 leukemic cells were transplanted into PI3KδKI mice (147). Here, CD8A is linked to B-cell chronic lymphocytic leukemia.