APC and Intussusception: We found that several DEGs between RV5V, and control children have been reported to be associated with intussusception (Figure 2) and abnormal morphology of midgut (Figure S1); e.g. gene APC, that is up-regulated in RV5V and RVinf, has been described to play a role in the development of a jejunal adenoma causing intussusception (29).