On further analysis by IPA, the genes provided 113 canonical pathways and 409 upstream regulators (Figure 3), of which neuroinflammation pathway appeared to be inhibited, while upstream regulators, CD23, CD28, and TCR, are inhibited, and camptothecin, and dexamethasone were activated in BPD. The gene discussed is CD28; the disease is bronchopulmonary dysplasia.