Since pharmacological activation of PKR has been shown to be well-tolerated in mice (López-Cara et al., 2011), and given that PKR is reported to play a role in the innate immune response to viral and parasitic infection (Tallóczy et al., 2006; Ogolla et al., 2013), we decided it was worthwhile to investigate PKR overexpression as a strategy for TB HDT. Here, EIF2AK2 is linked to parasitic infectious disease.