Interestingly, while mock-treated THP-PKR macrophages did not show a decrease in Mtb survival compared to THP-Ø macrophages at day 2 post-infection, rapamycin-treated THP-PKR macrophages showed a 45% reduction in luminescence relative to similarly treated THP-Ø macrophages (Figure 7). Here, EIF2AK2 is linked to infection.