Cháirez-Ramírez et al. described the anticancer activities of lupane-type triterpenes against breast cancer (32); molecular mechanisms have been revealed as well, mainly consisting in the modulation of proliferation or cell death-related signaling pathways (e.g. NF-κB, Wnt/β-catenin, PI3K/AKT, apoptosis) and resulting in extrinsic/intrinsic apoptosis and autophagy induction. This evidence concerns the gene AKT1 and breast carcinoma.