(1β, 2α, 3β, 19β, 23)-1,2,3,19,23-pentahydroxyolean-12-en-28-oic acid is a new phytochemical compound isolated from Euphorbia sieboldiana C.Morren & Decne., identified as a strong inhibitor of cervical cancer cells proliferation in a dose- and time-dependent manner; it exerts a selective cytotoxic activity by inducing apoptosis and cell cycle arrest in the G1 phase by inactivating the TNF-α–TAK1–IKK-NF-κB axis and TNF-α–stimulated NF-κB activity and subsequently down-regulating the NF-κB target genes. The gene discussed is NFKB1; the disease is cervical cancer.