CXCR4 and breast cancer: The study revealed that saikosaponins are able to target a multitude of proteins such as the apoptosis regulator Bcl-2, CXCR4, ATP-dependent RNA helicase DDX5, protein kinase C alpha and proto-oncogene tyrosine-protein kinase Src; in addition, in terms of involved mechanisms against breast cancer, saikosaponins regulate several key signaling pathways (e.g. PI3K-AKT signaling pathway, EGFR tyrosine kinase inhibitor resistance, etc.)(132).