and found strongly active as cell proliferation inhibitor in both ER positive (MCF-7) and negative (MDA-MB-231) breast cancer through the activation of p38 and ERK1/2 kinases pathways (138); the investigators established that asiatic acid induce mitochondrial apoptosis and S-G2/M cell cycle arrest by modulating the ERK1/2 cascade and the p38 pathway, respectively. This evidence concerns the gene MAPK3 and breast carcinoma.