Tumor growth inhibition;miR-27a suppression and induced expression of the miR-27a-regulated gene “ZBTB10”Tumor growth inhibition; Decreased the expression of VEGF and induced proteasome-dependent degradation of the transcription factors specificity protein 1 (Sp1), Sp3, and Sp4Decreased tumor volumeInhibition of breast cancer growthInhibition of glycolytic activity. The gene discussed is SP3; the disease is neoplasm.