AKT1 and neoplasm: Inhibited tumor incidence and burden, reversed histopathological alteration without toxicity, suppressed abnormal cell proliferation; upregulation of pro-apoptotic protein Bax and down-regulation of antiapoptotic Bcl2.Tumor growth suppression; induction of apoptosis and G0/G1 phase cell cycle arrest via the regulation of PI3K/AKT pathway.Significant reduction of tumor mass and size