Moreover, betulinic acid displays protective and therapeutic efficiency on cancer-associated bone pathologies such as breast cancer metastasis (136); its effects in the cycle of osteolytic bone metastasis were investigated, revealing that the cell viability and synthesis of the parathyroid hormone-related protein (PTHrP) which acts as a major osteolytic factor were significantly reduced. The gene discussed is PTHLH; the disease is breast cancer.