We also detected the age-related effect of rs1867277 (FOXE1) conferring the higher risk for PTC in patients older than 55 years and the association of rs7267944 (DHX35) with PTC risk in males and that of rs6983267 (POU5F1B/CCAT2) with more advanced tumor pT stage. The gene discussed is POU5F1B; the disease is neoplasm.