The functional role of DIRC3 lncRNA is likely to be that of tumor suppressor, and its relevance to thyroid cancer (8, 9) and other human malignancies such as, originally, familial renal cancer (43), melanoma (44), breast cancer (45) and laryngeal squamous cell carcinoma (46) has been reported. Here, DIRC3 is linked to laryngeal squamous cell carcinoma.