GWAS findings and consequent independent replication studies have convincingly demonstrated robust associations of rs965513 (FOXE1, forkhead box E1 and/or PTCSC2, papillary thyroid carcinoma susceptibility candidate 2; chromosome 9q22.33), rs944289 (PTCSC3, papillary thyroid carcinoma susceptibility candidate 3 and/or NKX2-1, NK2 homeobox 1; 14q13.3), rs1867277 (FOXE1; 9q22.33), rs2439302 (NRG1, neuregulin 1; 8q12) and rs966423 (DIRC3, disrupted in renal carcinoma 3; 2q35) SNPs with differentiated thyroid cancer, principally PTC (15–27), reviewed in (28). This evidence concerns the gene DIRC3 and thyroid gland papillary carcinoma.