We therefore aimed to examine the six well-described SNPs discussed above, namely rs965513 (FOXE1/PTCSC2, 9q22.33), rs944289 (PTCSC3/NKX2-1, 14q13.3), rs1867277 (FOXE1; 9q22.33), rs2439302 (NRG1, 8q12), rs966423 (DIRC3, 2q35) and rs6983267 (POU5F1B/CCAT2, 8q24.2), and two SNPs newly discovered to be associated with thyroid cancer (10), rs10136427 (BATF, 14q24.3) and rs7267944 (DHX35, 20q12) in a relatively large case–control series. The gene discussed is DIRC3; the disease is thyroid cancer.