In recent pharmacological developments for stroke, attenuation of microcirculatory disturbances has relied on ablation of single factors in stroke pathogenesis with interventions including recombinant tissue plasminogen activator (rtPA), antioxidants, anti-intercellular adhesion molecule-1 (ICAM-1) antibodies, calcium-stabilizing agents, and anti-excitotoxic agents (10). This evidence concerns the gene PLAT and Stroke.