Some of these high ACE2 expression brain nuclei are very important for normal brain functions, such as the paraventricular nuclei of the thalamus (involved in the control of wakefulness, feeding, appetitive motivation, drug addiction, regulation of stress and negative emotional behavior, and epilepsy) (40, 41), the raphe nuclei (the main serotoninergic nuclei in the brain) (42), and tuberomammillary nucleus (the main histaminergic nuclei in the brain) (43). The gene discussed is ACE2; the disease is epilepsy.