“The NALP3 inflammasome is involved in the innate immune response to amyloid-β” (2018) and had 1,294 citations; “NLRP3 is activated in Alzheimer”s disease and contributes to pathology in APP/PS1 mice”, published by M.T. Heneka et al. (2013), which was with 961 citations; and the third was 889 citations, “The role of inflammation in depression: from evolutionary imperative to modern treatment target” (2016) (Table 5). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.