The top 20 KEGG pathway enrichments were displayed based on the threshold of FDR < 0.01; for instance, AGE-RAGE signal transduction pathway in diabetes-related complications (ko04933), pathways in cancer (ko05200), fluid shear stress and atherosclerosis (ko05418), pancreatic cancer (ko05212), IL-17 signal transduction pathway (ko04657), hepatitis B (ko05161), relaxin signal transduction pathway (ko04926), TNF signaling pathway (ko04668), Chagas disease (American trypanosomiasis) (ko05142), and endocrine resistance (ko01522), etc (Figure 4B). This evidence concerns the gene TNF and familial pancreatic carcinoma.