The top 20 KEGG pathway enrichments were displayed based on the threshold of FDR < 0.01; for instance, AGE-RAGE signal transduction pathway in diabetes-related complications (ko04933), pathways in cancer (ko05200), fluid shear stress and atherosclerosis (ko05418), pancreatic cancer (ko05212), IL-17 signal transduction pathway (ko04657), hepatitis B (ko05161), relaxin signal transduction pathway (ko04926), TNF signaling pathway (ko04668), Chagas disease (American trypanosomiasis) (ko05142), and endocrine resistance (ko01522), etc (Figure 4B). The gene discussed is TNF; the disease is American trypanosomiasis.