TNF and hepatitis B virus infection: After KEGG enrichment analysis, it was found that the five flavonoids could potentially suppress liver fibrosis through multiple pathways, including pathways in cancer, the AGE-RAGE signal transduction pathway in diabetes-related complications, fluid shear stress and atherosclerosis, the IL-17 signal transduction pathway, the relaxin signal transduction pathway, hepatitis B, and the TNF signaling pathway, etc (Figures 4B,C).