CCL2 and Hepatic fibrosis: Based on results of network pharmacology, it was known that flavonoids can possibly suppress liver fibrosis by inhibiting the IL-17 signaling pathway, which includes NF-κB, AP-1, IL-6, IL-1β, TNFα, IFN-γ, CCL2, COX2, MMP1, MMP3, and MMP9.