Chang et al. (2014) described 24 pregnancies in patients with CAPS, reporting a lower miscarriage rate in women on anakinra than in those treated with other drugs (10% vs. 30%) suggesting anakinra use may have a protective effect on pregnancy outcomes for patients with IL-1-driven disease. Due to the scantiness of available data on the safety of IL-1 antagonists during conception, until additional information is available, these agents are not currently recommended during pregnancy and their discontinuation should be considered once pregnancy is confirmed (Sammaritano et al., 2020). Here, IL1B is linked to cryopyrin-associated periodic syndrome.