The level of TGF-β in patients with MCI (47.02 ng/ml) was the highest and significantly increased compared with patients with moderate-to-severe AD-related dementia (the value of p was 0.002), the group that had the lowest level of TGF-β (34.83 ng/ml; Table 1 and Figure 1). This evidence concerns the gene TGFB1 and Alzheimer disease.