GRIN2B and memory impairment: It has been shown that Aβ oligomers binding to or near NMDA receptors inhibits synaptic activity by excessive activation of extrasynaptic NMDA receptors (Decker et al., 2010a), particularly those containing the NR2B subunit, thus promoting cell death pathways (Li et al., 2011), synaptic damage and memory impairment.