Several studies indicate that mRNA and protein levels of NMDA and AMPA receptors subunits are reduced in moderate and severe AD (Yasuda et al., 1995; Hynd et al., 2001, 2004; Sze et al., 2001), and that synaptic scaffold proteins SYN-1 and PSD-95 are also reduced in AD and in hAPP transgenic mice (Pham et al., 2010; Shao et al., 2011). This evidence concerns the gene DLG4 and Alzheimer disease.