Mammalian GLUT1 and SGLT1 and 2 have also been shown to be dynamically upregulated upon hypoglycemia or other insults like oxygen and glucose deprivation as a result of ischemia (Boado and Pardridge, 1993; Kumagai et al., 1995; Nishizaki et al., 1995; Nishizaki and Matsuoka, 1998; Simpson et al., 1999, reviewed in Elfeber et al., 2004; Enerson and Drewes, 2006; Vemula et al., 2009; Yu et al., 2013; Patching, 2016; Rehni and Dave, 2018). This evidence concerns the gene SLC5A1 and Hypoglycemia.