DARS1 and hypomyelination with brain stem and spinal cord involvement and leg spasticity: Reduced PPI was present in severely affected Dars1D367Y/− mice as well as in mildly affected heterozygous Dars1-null mice (Fröhlich et al., 2017), suggesting to test for ASR and PPI in the clinical context as they might support an early diagnosis of HBSL.