Building from previous HCI studies, which detail computationally ascertained morphological changes in a single cell-type (Morrison and Filosa, 2013; Verdonk et al., 2016; Fernández-Arjona Md et al., 2017; Morrison et al., 2017; Heindl et al., 2018; York et al., 2018; Otxoa-de-Amezaga et al., 2019), this study revealed significant post-stroke morphological changes in 19 different cellular parameters in IBA1+, GFAP+, NeuN+, FactorVIII+, and DCX+ areas post-pMCAO. Here, AIF1 is linked to stroke disorder.