In addition, several independent studies have reported the involvement of genes encoding endolysosomal proteins in AD such as INPPL1 (SHIP2) (Mostafavi et al., 2018), Synaptojanin-1 (SYNJ1) (Miranda et al., 2018) and phospholipase D3 (PLD3) (Cruchaga et al., 2014). This evidence concerns the gene INPPL1 and Alzheimer disease.