Non-modifiable risk factors of AD include aging, female sex, and genetic risks, such as carrying the apolipoprotein E (APOE) e4 allele (Corder et al., 1993), whereas risk factors, such as diabetes mellitus (DM), hypertension (HTN), obesity, smoking, excessive alcohol consumption over 168 g weekly, and educational attainment, are potentially modifiable (Lourida et al., 2019). This evidence concerns the gene APOE and Alzheimer disease.