We selected ADH1C rs2241894 (ADH1C, chr4: 99344976, Synonymous Variant, c.453 A > T,C, p.Thr151 =), ADH1B rs1229984 (chr4:99318162, Missense Variant, c.143A > G, p.His48Arg), ALDH1B1 rs2073478 (chr9:38396068, c.320G > A, p.Arg107His), ALDH2 rs886205 (G > A, promoter, 5’-untranslated region), ALDH2 rs4767944 (C > G,T, Intron Variant), ALDH2 rs4648328 (C > T, intron variant, intron 3), and ALHD2 rs671 (G > A, missense variant Glu504Lys, exon 12) based on previous evidence of their association with alcohol dependence (Edenberg and Foroud, 2013). The gene discussed is ADH1B; the disease is alcohol dependence.