This study did not find associations between AD and ADH1B (rs1229984), ALDH1B1 (rs2073478), and ALDH2 (rs886205, rs4767944, rs4648328, and rs671), indicating that ADH1B, ALDH1B1, and ALDH2 played no role in the relationship between alcohol and AD. Here, ALDH1B1 is linked to Alzheimer disease.