ACE2 and infection: In the brain, ACE2 is expressed only in endothelium and vascular smooth muscle cells, which suggests that infection of neurons requires alternate routes of entry (Hamming et al., 2004) It has been shown that SARS-CoV can use alternate receptors such as CD209L for infection and pathogenesis (Jeffers et al., 2004; Yang et al., 2004), and uses cellular receptor neurophilin-1 to invade olfactory bulb epithelium (Cantuti-Castelvetri et al., 2020).