MTOR and neurodevelopmental disorder: Based on this scenario, FCD II, cortical tubers (tuberous sclerosis complex), and hemimegalencephaly (HME), which share neuropathological features such as cortical dyslamination, DNs, and BCs, represent a continuum of the same mTOR-associated neurodevelopmental disorder, with higher brain mosaic rates in HME compared with FCD II (D'Gama et al., 2015; Jansen et al., 2015; Mirzaa et al., 2016; Marsan and Baulac, 2018; Baldassari et al., 2019b; Sim et al., 2019).