MTOR and isolated focal cortical dysplasia type II: For FCD type II, most of the detected pathogenic variants converged in single genes regulating the mammalian target of rapamycin (mTOR) pathway, essential in neuronal growth and migration (Lim et al., 2015; Nakashima et al., 2015; Mirzaa et al., 2016; Moller et al., 2016).