AKT1 and isolated focal cortical dysplasia type IIa: Variants of unknown significance in the AKT1 gene were detected in FCD type IIa and IIb tissues (Avansini et al., 2018; Kobow et al., 2019), Baldassari et al. (2019b) reported two patients with FCD IIa with a somatic missense mutation (p.Glu17Lys) in AKT3, with VAF of 1.1–2.3%.