IL6 and Insulin resistance: Specifically, IL-6 signaling induces insulin resistance, alters protein, lipid, and fatty acid metabolism [85], and induces anemia [28] and anorexia [25], with consequent impairment of nutritional intake and utilization of energy substrates and microelements (e.g., glucose, iron, and zinc) that are fundamental for the activity of the main lymphocyte energy metabolic pathways (Fig. 3).