The authors implanted ES-2 ovarian cancer cells intraperitoneally to simulate disseminated abdominal disease and malignant ascites formation and found severe weight loss with progressive muscle wasting via enhanced muscle protein catabolism associated with elevated tumor-derived IL-6 levels in plasma and ascites, elevated phospho-STAT3, reduced levels of phosphorylated AKT, and altered mitochondrial homeostasis and metabolism. Here, STAT3 is linked to ovarian carcinoma.