PARK7 and obesity due to melanocortin 4 receptor deficiency: Of note, among the top-upregulated genes, Park7 is noteworthy because it is closely associated with human T2DM, and deficiency of Park7 results in glucose intolerance and dysregulation of oxidative stress.74Flot1 was found to be consistently repressed in the liver of individuals with obesity, hyperphagia, and T2DM.