Although a pooled analysis was not performed due to the limited number of related studies, it is noteworthy that Jab1 overexpression was not correlated with DFS of patients with laryngeal squamous cell carcinoma in Dong et al’s study; however, the other four studies indicated Jab1 overexpression as a prognostic factor for RFS, DFS and PFS in cancers. This evidence concerns the gene COPS5 and cancer.