Based on data from the Gene Expression Profiling Interactive Analysis database (http://gepia.cancer‐pku.cn/index.html) and other related articles, Jab1/COPS5 overexpression has been reported in various cancers, including hepatocellular carcinoma (HCC), breast cancer, non‐small cell lung cancer and nasopharyngeal carcinoma11, 12, 13, 14, 15, 16 In addition, an increasing number of studies have revealed that Jab1 overexpression is associated with poor prognosis and clinicopathological characteristics in a variety of cancers, such as HCC, breast cancer and colorectal cancer.12, 14, 17. This evidence concerns the gene COPS5 and hepatocellular carcinoma.