Notably, we found that four out of the six tumor types analyzed here have decreased cytosolic DNA sensing pathway signaling in p16-low vs. p16-high tumors (Supplementary Figure 4B); however, no correlation was found between CDKN2A and LMNB1 mRNA expression (Figure 4C), suggesting that additional mechanisms are at play in tumors with low p16 expression. Here, CDKN2A is linked to neoplasm.