Altogether, these data suggest that p16 may directly or indirectly regulate the transcription of both IL6 and CXCL8 and support the hypothesis that this is not a consequence of p16 suppression-mediated senescence bypass since suppression of p16 in both senescent and proliferating melanoma cells abrogates IL6 and CXCL8. This evidence concerns the gene CDKN2A and melanoma.