ALDH1A1 and non-small cell lung carcinoma: Treatment of cisplatin-resistant cell lines with components of the retinoic acid pathway (ATRA and retinol) significantly reduced the ALDH1+ve subpopulation across NSCLC cells representing large cell (H460), adenocarcinoma (H1299) and squamous cell (SKMES-1) histology (Fig. 2B).