In our study on the role of the long non-coding RNAs in AD, we found that NEAT1 is associated with the acetyltransferase P300/CBP complex and that knockdown of NEAT1 increases histone Kcr and decreases acetylation at H3K27, suggesting that NEAT1 mediates histone acetylation and inhibits histone crotonylation at the same lysine sites [8]. This evidence concerns the gene NEAT1 and Alzheimer disease.