In the present study, we confirmed that SDA could significantly increase the PGC-1α and Nrf2 expression in PC12/α-syn cells model as well as in the MPTP-induced PD animal model, indicating that neuroprotective effect of SDA may be partly mediated by reducing oxidative stress via upregulating antioxidant proteins and enhancing mitochondrial respiratory function through the PGC-1α/Nrf2 pathway. Here, NFE2L2 is linked to Parkinson disease.