A total of 5 loci (BACH2, VDR, STRADB, SPG7, and HLA-DRB1/DQA2) were identified to exhibit genome-wide significance in both eQTL and DNAm analyses and significant association between DNAm and eQTL (PDNAm->eQTL < 1 × 10−5, Additional file 2: Table S5), indicating genetic and methylation regulatory mechanisms driving BCC susceptibility. This evidence concerns the gene HLA-DRB1 and skin basal cell carcinoma.