In the current study, we generated hMSC-HAND2-AS1-Exos (exosomes derived from HAND2-AS1-overexpressing hMSCs); after the co-incubation of RA-FLSs with hMSC-HAND2-AS1-Exos, HAND2-AS1 level was remarkably elevated in RA-FLSs and also suppressed cell growth, mobility, and inflammation and induced cell apoptosis. The gene discussed is HAND2; the disease is rheumatoid arthritis.