HAND2 and rheumatoid arthritis: Then, we upregulated the level of HAND2-AS1 in RA-FLSs in vitro, and it was proved that HAND2-AS1 re-expression impaired the proliferation, invasion, migration, and inflammation and contributed to the apoptosis in RA-FLSs; thus, we knew that HAND2-AS1 was of great importance in the pathogenesis of RA.