HAND2 and rheumatoid arthritis: It was proved that co-transfection of miR-143-3p reversed the effects of HAND2-AS1 overexpression on the suppression of RA-FLS proliferation (Fig. 3b), migration (Fig. 3d), invasion (Fig. 3e), and inflammation (Fig. 3f), as well as the enhancement of cell apoptosis (Fig. 3c).