In particular, we intended to test the hypothesis that specific SNPs of the circadian clock genes, such as AANAT (arylalkylamine N-acetyltransferase), CLOCK (clock circadian regulator), NPAS2 (neuronal PAS domain protein 2), PER1 (period circadian clock 1), PER2 (period circadian clock 2), RORA (retinoic acid-related orphan receptor A), and TIMELESS (timeless circadian clock) could significantly influence the predisposition to develop cutaneous melanoma or the outcome of melanoma bearing patients. This evidence concerns the gene RORA and melanoma.