To determine the mechanism underlying the single nucleotide polymorphism in breast cancer suppressor BRCA1-related associated protein (BRAP, rs3782886) and aldehyde dehydrogenase 2 (ALDH2, rs671) and hypertension, a multi-faceted analysis was performed in a simple general elderly population model (1313 older Japanese aged 60–98 years). The gene discussed is BRAP; the disease is Hypertension.