In support of this notion, tumor-secreted molecules such as parathyroid hormone-related peptide (PTHrP) and interleukin 8 (IL-8) enhance osteoclast-mediated bone resorption, thereby increasing the local availability of bone matrix storage proteins such as transforming growth factor-β (TGF-β) [5]. The gene discussed is CXCL8; the disease is neoplasm.