The impaired apolipoprotein B-100 synthesis in NASH patients could be related to the increased cellular FFA level, disturbed redox balance, hyperinsulinemia and decreased expression, all of which were shown to hamper apolipoprotein B-100 synthesis and VLDL assembly, thus resulting in lipid accumulation in the liver [39]. Here, APOB is linked to metabolic dysfunction-associated steatohepatitis.