Our recent study showed that persistently high insulin levels result in a significant decrease in the expression of phosphorylated AKT (p‐AKT) and FoxO1 (p‐FoxO1), mitochondrial membrane potential (ΔΨm) and cardiac function in db/db mice, which indicates the links between altered insulin signalling and mitochondria in DCM.5 The gene discussed is FOXO1; the disease is familial dilated cardiomyopathy.