When compared to the control mice, high-fat dieted and/or IL-10-deficient mice showed obvious histological changes at glomerulus and tubules, such as glomerulomegaly, glomerulosclerosis (arrow, Fig. 3B, C, D), glomerular capillary dilation, thickened glomerular basement membrane (arrow head, Fig. 3B, D), mesangial matrix expansion, podocyte hypertrophy, tubule lumens enlargement, interstitial cell necrosis and shortened tubular epithelium. This evidence concerns the gene IL10 and glomerulosclerosis.